Response to “A threshold without a map: Why isodose normalization must accompany D95/D2 TCP cutpoints”

Key Points

• Effective isodose normalization enhances both D95 and D2 values for better tumor control probabilities.
• D95 and D2 metrics are essential benchmarks in assessing the efficacy of radiation therapy treatments.
• Observational analysis highlights the necessity of integrating isodose normalization in establishing TCP cutpoints.
• Improved treatment protocols could arise from this analysis, suggesting a need for broader adoption in practice.