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March 3, 2026Journal of Advanced Research1 citationsOpen Access

Unmasking human T cell receptor germline diversity: 335 novel alleles identified in 47 Pangenome reference individuals using the gAIRR Suite

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YYYu-Hsuan YangCYChi-Yuan YaoMLMao-Jan Lin

Key Points

  • Advances in T cell receptor germline diversity reveal 335 novel alleles in 47 individuals, enhancing immunogenetic understanding.
  • Key findings include a comprehensive gAIRR resource, supporting precise genotyping and exprAIRR profiling of T cell receptors.
  • The research utilizes a robust analytic framework to generate and validate novel alleles, helping characterize immunogenomic traits.
  • Study implications suggest potential improvements in vaccines and immunotherapies through accurate, population-diverse references.

Abstract

This study significantly expands the known landscape of human TR germline diversity and provides a rigorously validated, population-diverse resource comprising novel alleles, flanking sequences, RSS profiles, and supporting analytical tools. These improved gAIRR references are essential for accurate germline genotyping and exprAIRR profiling, and will enable improved detection of immunogenetic associations. Our findings advance precision immunogenomics and support the development of ancestry-independent yet diversity-comprehensive genotyping, vaccines, and immunotherapies.

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Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/69a75f58c6e9836116a2aa87https://doi.org/10.1016/j.jare.2026.01.053
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