PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
March 3, 2026Journal of Advanced Research1 citationsOpen Access

Unmasking human T cell receptor germline diversity: 335 novel alleles identified in 47 Pangenome reference individuals using the gAIRR Suite

View Full Paper
YYYu-Hsuan YangCYChi-Yuan YaoMLMao-Jan Lin

Key Points

  • Advances in T cell receptor germline diversity reveal 335 novel alleles in 47 individuals, enhancing immunogenetic understanding.
  • Key findings include a comprehensive gAIRR resource, supporting precise genotyping and exprAIRR profiling of T cell receptors.
  • The research utilizes a robust analytic framework to generate and validate novel alleles, helping characterize immunogenomic traits.
  • Study implications suggest potential improvements in vaccines and immunotherapies through accurate, population-diverse references.

Abstract

This study significantly expands the known landscape of human TR germline diversity and provides a rigorously validated, population-diverse resource comprising novel alleles, flanking sequences, RSS profiles, and supporting analytical tools. These improved gAIRR references are essential for accurate germline genotyping and exprAIRR profiling, and will enable improved detection of immunogenetic associations. Our findings advance precision immunogenomics and support the development of ancestry-independent yet diversity-comprehensive genotyping, vaccines, and immunotherapies.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/69a75f58c6e9836116a2aa87https://doi.org/10.1016/j.jare.2026.01.053
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Minimap2: pairwise alignment for nucleotide sequences2018 · 17,520 citations
  2. 2The HLA genomic loci map: expression, interaction, diversity and disease2009 · 806 citations
  3. 3Immunosequencing: applications of immune repertoire deep sequencing2013 · 216 citations
  4. 4Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles2017 · 173 citations
  5. 5RSSsite: a reference database and prediction tool for the identification of cryptic Recombination Signal Sequences in human and murine genomes2010 · 88 citations