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March 3, 2026Journal of the Neurological Sciences2 citationsOpen Access

Long-term cognitive outcomes and persistent executive dysfunction in LGI1 autoimmune encephalitis

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DSDror ShirTel Aviv Sourasky Medical CenterOAOrna AizensteinTel Aviv UniversityYPYael ParanTel Aviv University

Key Points

  • Cognitive outcomes improve after immunotherapy, yet executive dysfunction often remains a long-term deficit.
  • Older age is a significant predictor of poorer cognitive outcomes, indicating an age-related vulnerability.
  • Observational analysis investigates cognitive changes following immunotherapy for LGI1 autoimmune encephalitis in older patients.
  • Findings suggest a need for targeted interventions for older individuals to improve long-term cognitive recovery.

Abstract

Cognitive outcomes in LGI1 autoimmune encephalitis improve after immunotherapy, yet executive dysfunction frequently persists as a long-term deficit. Older age independently predicts poorer outcomes, suggesting that age-related vulnerability may limit recovery.

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Cite This Study

Shir et al. (2026) studied this question.

synapsesocial.com/papers/69a76017c6e9836116a2c80bhttps://doi.org/10.1016/j.jns.2026.125789
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