Ferroptosis and Nrf-2 signaling: a redox tug of war in leishmaniasis pathogenesis and host directed therapy

Key Points

• Ferroptosis plays a crucial role in the pathogenesis of leishmaniasis, influencing the disease's progression.
• Nrf-2 signaling impacts cellular responses, activating antioxidant defenses against oxidative stress.
• This analysis highlights how targeting these pathways may enhance host directed therapy outcomes.
• Understanding the balance between ferroptosis and nrf-2 signaling could improve treatment strategies for leishmaniasis.