Oral delivery of GLP-1 analogues by recombinant Lactococcus lactis restores pancreatic islet structure through intestinal mucosal absorption in diabetic mice

Key Points

• Improved pancreatic islet structure was observed, indicating potential therapeutic benefits of GLP-1 analogues.
• Specifically, the oral delivery of GLP-1 analogues using Lactococcus lactis positively affected diabetes management.
• Analysis focused on the capacity of intestinal mucosal absorption to enhance therapeutic effects in a diabetic model.
• This research highlights a promising new approach for diabetes treatment with oral formulations of GLP-1.