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March 3, 2026Frontiers in Oncology0 citationsOpen Access

Glutamine alleviates radiation-induced intestinal injury in rats via the mTOR/Notch1 axis

HLHeng LuXNX. NiXLXinyu Liang

Key Points

  • Glutamine provides significant protection against radiation-induced intestinal injury, promoting recovery mechanisms.
  • Protection is associated with modulation of the mTOR/Notch1 signaling pathway, which helps alleviate Notch1 overactivation.
  • The study utilized a rat model to examine the protective effects of glutamine following radiation exposure.
  • Findings underscore glutamine's promise as a therapeutic agent, though further investigation may be needed for clinical application.

Abstract

Collectively, these results demonstrate that Gln confers robust protection against RIII by regulating the mTOR/Notch1 axis, alleviating Notch1 overactivation, and promoting GC differentiation. These findings provide valuable mechanistic insight and experimental support for Gln as a potential therapeutic agent to prevent or mitigate radiation-induced intestinal injury.

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Cite This Study

Lu et al. (2026) studied this question.

synapsesocial.com/papers/69a7605dc6e9836116a2d0a8https://doi.org/10.3389/fonc.2026.1735401
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