Decoding the immunopharmacological basis of ECT-induced clozapine level elevation: Insights from a quantitative systems pharmacology model

Key Points

• Clozapine levels significantly elevated following ECT treatment, indicating an important drug interaction.
• The maximum observed increase in clozapine levels was notably influenced by the immunopharmacological basis.
• Quantitative systems pharmacology modeling assessed the interactions and mechanisms at play in this elevation.
• Findings may indicate new approaches in optimizing clozapine therapy based on ECT treatment, highlighting a need for further research.