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March 3, 2026Aging Clinical and Experimental Research1 citationsOpen Access

Change in loneliness and subsequent cardiometabolic Multimorbidity among middle-aged and older adults: results from two east asian prospective cohorts

MWMenglin WangHenan Provincial People's HospitalHWHao WangShandong University

Key Points

  • Increased loneliness is linked to greater risk of cardiometabolic multimorbidity (CMM).
  • Individuals with persistent loneliness show the strongest association with CMM outcomes.

Structured PICO

Are changes in loneliness associated with the risk of subsequent cardiometabolic multimorbidity in middle-aged and older adults?

P
Population
Middle-aged and older adults from two East Asian prospective cohorts
I
Intervention
Changes in loneliness (exposure)
O
Outcome
Subsequent cardiometabolic multimorbidity (CMM)

Loneliness is a dynamic and potentially modifiable risk factor for cardiometabolic multimorbidity, suggesting that targeted interventions may help prevent CMM in older adults.

Abstract

Changes in loneliness were associated with an increased risk of subsequent CMM in both China and South Korea, with the strongest associations observed among individuals experiencing persistent loneliness. These findings indicate that loneliness is a dynamic and potentially modifiable risk factor for cardiometabolic multimorbidity across different sociocultural contexts. Early identification and targeted interventions addressing loneliness may contribute to the prevention of CMM among middle-aged and older adults.

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69a760a2c6e9836116a2d94bhttps://doi.org/10.1007/s40520-026-03331-5
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