Proteomics landscape of early T-cell precursor acute lymphoblastic leukemia reveals deficient oxidative phosphorylation signatures

Key Points

• Deficient oxidative phosphorylation signatures characterize early T-cell precursor acute lymphoblastic leukemia.
• A distinct proteomics landscape reveals critical metabolic pathways affected in the leukemia type.
• Analysis of protein expression compared with healthy controls highlights key biomarkers of disease.
• Understanding these metabolic deficits may inform targeted therapies for T-cell precursor leukemia.