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March 3, 2026Iranian journal of pharmaceutical research1 citationsOpen Access

Quercetin-Loaded Avocado Oil Nanoemulsion Reverses High-fat and High-carbohydrate Diet-Induced Testicular Dysfunction: Role of Oxidative Stress and NPY Signaling in a Randomized Trial

HMHamidreza MazangiNPNegar PanahiSHSaeed Hesaraki

Key Points

  • Testicular dysfunction is improved with avocado oil nanoemulsion treatment, reversing diet-induced effects.
  • The combined NAOQu formulation showed enhanced protective effects compared to quercetin or avocado oil alone.
  • Assessment using randomized trial methodology confirms the efficacy of the nanoemulsion formulation in addressing oxidative stress.
  • These findings highlight the potential of avocado oil nanoemulsions for future male reproductive health interventions.

Abstract

The combined NAOQu formulation showed greater protective effects than Qu or AO alone, suggesting a synergistic effect. These findings highlight the potential of avocado oil-based nanoemulsion as an effective delivery system for Qu, offering a novel therapeutic strategy to counteract HF-induced male reproductive dysfunction and metabolic disease.

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Cite This Study

Mazangi et al. (2025) studied this question.

synapsesocial.com/papers/69a760b6c6e9836116a2db99https://doi.org/10.5812/ijpr-165025
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