Mechanistic insights into PM2.5-induced myopia in mice: Role of NRF2/HIF-1α signaling and therapeutic potential of sulforaphane

Key Points

• Myopia development shows a direct correlation with PM2.5 exposure and NRF2/HIF-1α activation.
• Data indicates significant changes in eye curvature measurements linked to prolonged PM2.5 exposure.
• Investigation employs a mouse model to explore the underlying signaling pathways involved in myopia.
• Findings highlight the therapeutic promise of sulforaphane in mitigating PM2.5-induced myopia effects.