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March 3, 2026Ain Shams Engineering Journal2 citationsOpen Access

Enhanced Detection of Diabetic Retinopathy using GAI-Net: Deep Learning Model based on GAN with Autoencoder

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CRChilukuri RajithaPPP PraveenKRK Rajchandar

Key Points

  • GAI-Net achieves a remarkable detection accuracy of 0.99, significantly enhancing diabetic retinopathy diagnosis.
  • The model utilizes a hybrid approach, integrating generative adversarial networks and autoencoders for improved feature representation.
  • Comparative analysis against models like EfficientNet GAN shows GAI-Net's superior performance in classifying DR severity levels.
  • Highlights the significance of exploiting hybrid architectures for automated medical image analysis in diabetic retinopathy.

Abstract

Diabetic Retinopathy (DR) is a serious illness associated with diabetes and is one of the leading causes of universal visual impairment. Early and proper diagnosis is crucial to prevent permanent eye damage. The proposed paper introduces a new hybrid deep learning framework, GAI-Net, that uses Generative Adversarial Networks (GANs), Autoencoders, and InceptionV3 to detect DR in five levels of severity. The model addressed multiple issues in DR detection, including small datasets and class imbalance, through quality synthetic images and discriminative hierarchical features. Generative component increases data variation, and the discriminative modules increases the representation of the features and accuracy in recognition. To compare the performance of the proposed GAI-Net, a comparative analysis was undertaken with advanced models, including traditional GANs, DCGAN, Attention-GAN, EfficientNet GAN, and InceptionV3 through the use of Kaggle dataset images are included. The obtained results indicate that GAI-Net outperforms all other comparative models, achieving a detection accuracy of 0.99 and an F1-score of 0.98, which is a high level of effectiveness. The methodology shows the strengths of combining the generative and discriminative deep learning methods in medical image analysis. GAI-Net is able to diagnose diabetic retinopathy with a scalable, accurate, and entirely automatic model by constructing balanced datasets and improving the encoding of features. The current research paper explains the potential use of hybrid architectures in computer-aided diagnosis, as it helps strengthen the development of the next-generation tools to find diabetic retinopathy with extensive medical uses.

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Cite This Study

Rajitha et al. (2026) studied this question.

synapsesocial.com/papers/69a76146c6e9836116a2f0bahttps://doi.org/10.1016/j.asej.2026.104050
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Early detection of diabetic retinopathy2018 · 228 citations
  2. 2Automated detection and classification of fundus diabetic retinopathy images using synergic deep learning model2020 · 299 citations
  3. 3Diabetic Retinopathy Detection Using Prognosis of Microaneurysm and Early Diagnosis System for Non-Proliferative Diabetic Retinopathy Based on Deep Learning Algorithms2020 · 306 citations
  4. 4DL-CNN-based approach with image processing techniques for diagnosis of retinal diseases2021 · 139 citations
  5. 5An overview of artificial intelligence in diabetic retinopathy and other ocular diseases2022 · 123 citations