Evaluation of drug-excipient compatibility of ibuprofen with eggshell-derived calcium citrate using FTIR, DSC, and molecular docking studies

Key Points

• Compatibility of ibuprofen with eggshell-derived calcium citrate is validated through a series of detailed analyses.
• Significant interaction between the drug and excipient is indicated by FTIR and DSC techniques, suggesting stability.
• Analysis employs molecular docking studies to investigate the binding affinities between ibuprofen and calcium citrate.
• Highlights the potential for using natural sources like eggshell in pharmaceutical formulations, necessitating further exploration.