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March 3, 2026Journal of Fluorine Chemistry0 citations

Regioselective syntheses of 5-polyfluoroalkyl-3-hydroxyfuranes by oxidative cyclization of 6-polyfluoroalkyl-1-arylhexane-1,3,5-triones with hypervalent iodine(III) compounds

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IKIvan A. KochnevABAlexey Y. Barkov

Key Points

  • The synthesis achieves regioselective formation of 5-polyfluoroalkyl-3-hydroxyfuranes through oxidative cyclization.
  • Utilizing hypervalent iodine(III) compounds results in a unique product formation profile, enhancing synthetic efficiency.
  • The method showcases versatility in creating functionalized furanes from 6-polyfluoroalkyl-1-arylhexane-1,3,5-triones under controlled conditions.
  • This approach may enable new applications in medicinal chemistry and materials science with further exploration.
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Cite This Study

Kochnev et al. (2026) studied this question.

synapsesocial.com/papers/69a76555badf0bb9e87d8c19https://doi.org/10.1016/j.jfluchem.2026.110542
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