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March 3, 2026Neurosurgical Review0 citations

Drug-induced hypertension is associated with improved survival in glioblastoma patients treated with bevacizumab: evidence from a time-to-event meta-analysis and meta-regression

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IKIrfan KesumayadiAKAtsushi KambeHAHidefumi Amisaki

Key Points

  • Survival improved as drug-induced hypertension emerged in glioblastoma patients.
  • The analysis identified a significant correlation with improved survival rates under bevacizumab treatment.
  • Employing a time-to-event meta-analysis allowed for comprehensive data synthesis across multiple studies.
  • Implications suggest hypertension could be a beneficial response to treatment; further exploration needed.
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Cite This Study

Kesumayadi et al. (2026) studied this question.

synapsesocial.com/papers/69a7658abadf0bb9e87d97a1https://doi.org/10.1007/s10143-025-04088-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bevacizumab-Induced Hypertension as a Potential Physiological Clinical Biomarker for Improved Outcomes in Patients With Recurrent Glioblastoma Multiforme: A Systematic Review2022 · 7 citations
  2. 2Updating guidance for reporting systematic reviews: development of the PRISMA 2020 statement2021 · 3,011 citations
  3. 3Bevacizumab-induced hypertension in patients with glioblastoma: a systematic review and meta-analysis2024 · 2 citations
  4. 4Arterial hypertension and bevacizumab treatment in glioblastoma: no correlation with clinical outcome2009 · 21 citations
  5. 5VASCULAR ENDOTHELIAL GROWTH FACTOR A IN PATIENTS WITH ESSENTIAL HYPERTENSION2019 · 2 citations