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March 3, 2026Microbial Cell Factories2 citationsOpen Access

Metabolic engineering of Corynebacterium glutamicum for high-yield de novo biosynthesis of 5-aminovaleramide, a promising bio-based monomer

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ASAnnalena SommerSPSarah PauliMKMichael Kohlstedt

Key Points

  • Corynebacterium glutamicum shows potential for high-yield de novo biosynthesis of 5-aminovaleramide—an important bio-based monomer.
  • Engineered strains produced 50% more 5-aminovaleramide compared to previous methods, enhancing viability for industrial applications.
  • Metabolic engineering strategies focused on optimizing specific pathways in Corynebacterium glutamicum to improve yield.
  • This approach highlights the importance of microbial systems for sustainable chemical manufacturing; further industrial applications are now encouraged.
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Cite This Study

Sommer et al. (2026) studied this question.

synapsesocial.com/papers/69a765ccbadf0bb9e87da7c6https://doi.org/10.1186/s12934-026-02922-1
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