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March 3, 2026Clinical Psychology Review5 citationsOpen Access

Ketamine-assisted psychotherapies for mental disorders: A historical overview and systematic review

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JVJKE VeraartUniversity Medical Center GroningenNSN. SchimmersUniversity Medical Center GroningenJBJ.J. BreeksemaUniversity Medical Center Groningen

Key Points

  • Positive clinical effects of ketamine-assisted psychotherapy are noted across various mental disorders, indicating its therapeutic potential.
  • The review highlights the necessity for well-controlled trials to establish optimal strategies for combining ketamine and psychotherapy.
  • This assessment explores both historical context and recent developments in clinical findings related to ketamine use in therapy.
  • Well-controlled trials are essential to understand possible synergistic effects of ketamine combined with psychotherapy interventions.

Abstract

Clinical effects are generally reported to be quite positive across psychiatric indications, however, there is a clear need for well-controlled trials to test for potential additive or synergistic effects of the combined use of ketamine and psychotherapy and to identify optimal therapeutic protocols.

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Cite This Study

Veraart et al. (2026) studied this question.

synapsesocial.com/papers/69a765d9badf0bb9e87dab32https://doi.org/10.1016/j.cpr.2026.102706
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