LINC00467 mediates PARP inhibitor resistance in high-grade serous ovarian cancer by regulating miR-485-5p/RAD50 axis

Key Points

• LINC00467 mediates resistance to PARP inhibitors, impacting treatment effectiveness.
• High levels of LINC00467 were correlated with increased RAD50 expression, affecting cancer cell survival.
• Analysis involved examining the regulatory relationship between miR-485-5p and RAD50 in cancer models.
• Findings highlight the need for targeted therapies addressing LINC00467 to improve treatment outcomes.