Florid lymphoid hyperplasia (FLH) is a rare entity with an unknown etiology. It may occur anywhere in the gastrointestinal tract, from the base of the tongue to the anus, but is more common at the terminal ileum and rectum. It often presents as an acute abdominal condition. Our case illustrates how FLH can closely mimic the clinical presentation of acute appendicitis. The resemblance can be so striking that it poses a significant diagnostic challenge, highlighting the importance of careful evaluation in such scenarios.
Raichur et al. (2026) studied this question.