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March 4, 2026Indian Journal of Pharmacology1 citations

Silymarin alleviates cisplatin-induced cachexia via modulating tripartite motif containing 63 (TRIM63) and myogenin

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SDSatadal DasUniversity of CalcuttaJJyotikaBirla Institute of Technology and Science, PilaniRPRitu PahujaBirla Institute of Technology and Science, Pilani

Key Points

  • This research aims to investigate how silymarin impacts cachexia induced by cisplatin, focusing on specific molecular pathways.
  • Experimental model using cisplatin to induce cachexia
  • Administration of silymarin
  • Assessment of TRIM63 and myogenin levels
  • Measurement of oxidative and inflammatory stress markers
  • Silymarin significantly reduces TRIM63 levels
  • Restores myogenin expression
  • Decreases markers of oxidative and inflammatory stress

Abstract

Silymarin attenuates cisplatin-induced cachexia through TRIM63 suppression, myogenin restoration, and reduced oxidative and inflammatory stress.

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Cite This Study

Das et al. (2026) studied this question.

synapsesocial.com/papers/69a7ccc3d48f933b5eed898fhttps://doi.org/10.4103/ijp.ijp_136_25
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