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March 4, 2026Acupuncture in Medicine0 citations

Effects of manual acupuncture on microglial polarization and the Sirt1/NF-κB pathway in a rat model of post-stroke depression

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MLMenghan LiFirst Teaching Hospital of Tianjin University of Traditional Chinese MedicineXYXinming YangFirst Teaching Hospital of Tianjin University of Traditional Chinese MedicineDRDawei RanFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine

Key Points

  • This research investigates how manual acupuncture affects microglial polarization and related signaling pathways in post-stroke depression.
  • Utilized a rat model of post-stroke depression
  • Applied manual acupuncture to assess its impact on microglial transformation
  • Examined changes in the Sirt1/NF-κB signaling pathway
  • Manual acupuncture promoted M2 microglia polarization and reduced M1 microglial activation
  • Resulted in a significant reduction of the inflammatory response
  • Improved depression-like behavior in the tested rats

Abstract

MA promoted the transformation of microglia from M1 to M2 in the prefrontal lobe of PSD rats, reduces the inflammatory response and improves depression-like behavior in rats. These effects were associated with activation of the Sirt/NF-κB pathway.

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69a7cd6ed48f933b5eed9b58https://doi.org/10.1177/09645284261423203
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  5. 5COMPARISON OF CORTICAL AND SUBCORTICAL LESIONS IN THE PRODUCTION OF POSTSTROKE MOOD DISORDERS1987 · 426 citations