What does this research mean for the field?

Plant-based biomanufacturing is a promising platform for the production of vaccines and drugs due to its rapid response, low cost, and low risk of human or animal pathogen contamination. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to review the development of plant bioreactors for vaccine and drug production.

March 5, 2026Chinese Science Bulletin (Chinese Version)0 citationsOpen Access

Plant-based Biomanufacturing for Vaccine and Drug Development

FXFen Xie YLYueyi Li GBGe Bai

Key Points

This research aims to review the development of plant bioreactors for vaccine and drug production.
Systematic review of plant bioreactors like tobacco and rice
Comparison of stable and transient expression strategies
Analysis of commercialized plant-derived vaccines and drugs
Identification of technology bottlenecks in protein purification
Exploration of future research directions for plant biomanufacturing
Highlighted advantages of plant bioreactors, including cost-effectiveness and safety
Outlined challenges in the purification of foreign proteins from plants
Provided insights into the market status of plant-derived vaccines and drugs
Suggested areas for further research to enhance production systems

Abstract

植物生物反应器凭借其响应速度快、成本较低以及不易感染人类或动物病原体等优势，已成为生物制造领域备受关注的新型表达平台。本文系统回顾了烟草、水稻等植物生物反应器在疫苗和药物生产中的发展历程，对比分析了稳定转化与瞬时转化两种表达策略的技术特点与适用范围，总结了植物源疫苗和药物的上市和临床应用情况，详细梳理了植物生物反应器表达纯化外源蛋白遇到的技术瓶颈和应用挑战，进一步展望了植物生物反应器的未来研究方向，为植物源疫苗与药物的生产和商品化提供了技术建议，以助力构建更完善的植物生物制造体系。

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Cite This Study

Xie et al. (2026) studied this question.

synapsesocial.com/papers/69a91d21d6127c7a504bfdf1 https://doi.org/10.1360/csb-2025-5652

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March 5, 2026Chinese Science Bulletin (Chinese Version)0 citationsOpen Access

Plant-based Biomanufacturing for Vaccine and Drug Development

FXFen Xie YLYueyi Li GBGe Bai

Key Points

This research aims to review the development of plant bioreactors for vaccine and drug production.
Systematic review of plant bioreactors like tobacco and rice
Comparison of stable and transient expression strategies
Analysis of commercialized plant-derived vaccines and drugs
Identification of technology bottlenecks in protein purification
Exploration of future research directions for plant biomanufacturing
Highlighted advantages of plant bioreactors, including cost-effectiveness and safety
Outlined challenges in the purification of foreign proteins from plants
Provided insights into the market status of plant-derived vaccines and drugs
Suggested areas for further research to enhance production systems

Abstract

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Cite This Study

Xie et al. (2026) studied this question.

synapsesocial.com/papers/69a91d21d6127c7a504bfdf1 https://doi.org/10.1360/csb-2025-5652

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