March 5, 2026Health Technology Assessment0 citationsOpen Access
Effectiveness of polyhexanide, chlorhexidine with neomycin and mupirocin for nasal methicillin-resistant Staphylococcus aureus (MRSA) decolonisation: non-inferiority RCT (TIDE)
The research aims to evaluate the effectiveness of various antiseptic agents in decolonising MRSA.
Conducted a non-inferiority randomized controlled trial (RCT)
Evaluated effectiveness of polyhexanide, chlorhexidine with neomycin, and mupirocin
Focused on nasal decolonisation of methicillin-resistant Staphylococcus aureus
Demonstrated no significant differences in decolonisation rates among the treatments
Indicated that polyhexanide and chlorhexidine with neomycin are as effective as mupirocin
Abstract
This synopsis presents independent research funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme as award number NIHR132718.