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March 5, 20260 citationsOpen Access

Intraoperative seizure in the setting of tumor resection: illustrative cases.

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TMThomas D. McCafferyJBJosephine BuclezHDHithardhi Duggireddy

Key Points

  • The aim is to explore hypocapnia as a modifiable risk factor for intraoperative seizures during tumor resection.
  • Illustrative cases of patients undergoing tumor resection with observed intraoperative seizures.
  • Analysis of hypocapnia's impact on seizure risk.
  • Emphasis on adherence to hyperventilation guidelines.
  • Hypocapnia was identified as a significant factor contributing to intraoperative seizures.
  • Management strategies targeting carbon dioxide levels could mitigate seizure risks.
  • The need for strict adherence to hyperventilation guidelines was reinforced.

Abstract

These cases highlight hypocapnia as a potentially modifiable risk factor for intraoperative seizures and underscore the need for judicious management. Given the risk of seizure induction under reduced cerebral blood flow, strict hyperventilation guidelines should be followed when tumors are in critical vascular territories. https://thejns.org/doi/10.3171/CASE25585.

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Cite This Study

McCaffery et al. (2026) studied this question.

synapsesocial.com/papers/69a91e1fd6127c7a504c1bd6https://doi.org/10.3171/case25585
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