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March 6, 2026Lishizhen medicine and materia medica research0 citations

italicWeiqi Decoction /italic(胃祺饮) alleviates chronic atrophic gastritis by regulating abnormalities in gastric mucosal cell proliferation and apoptosis

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JLJiale LiXFXiaoyan Fei

Key Points

  • This research aims to investigate the effects of Weiqi Decoction on gastric mucosal cell proliferation and apoptosis in chronic atrophic gastritis.
  • Examined gastric mucosal samples from CAG patients using immunohistochemistry and TUNEL method.
  • Compared PCNA, p21, p53, Caspase-3, cytochrome c, COX-2, NF-κB expression in treatment and control groups.
  • Conducted statistical analysis to evaluate changes in markers post-treatment.
  • Chronic atrophic gastritis patients showed significantly higher expression of seven biomarkers compared to superficial gastritis patients (P<0.05).
  • After Weiqi Decoction treatment, apoptosis decreased, and expression of p21, p53, COX-2 lowered (P<0.05).
  • Complete disappearance of atrophy and intestinal metaplasia correlated with a significant drop in apoptosis and biomarker expression (P<0.05).

Abstract

目的 探讨胃祺饮加减对慢性萎缩性胃炎(CAG)患者胃黏膜上皮细胞异常增殖与凋亡的改善作用。 方法 采用免疫组化法检测对照组(10例萎缩性胃炎患者、10例浅表性胃炎患者)及治疗组(61例胃祺饮加减治疗患者)胃黏膜组织中PCNA、p21、p53、Caspase-3、cytochrome c、COX-2、NF-κB的表达情况,TUNEL法检测细胞凋亡情况,并结合病理改变行统计学分析。 结果 与浅表性胃炎患者的胃黏膜上皮相比,慢性萎缩性胃炎患者胃黏膜上述7种指标表达及细胞凋亡均显著高于浅表性胃炎(PP0.05),其余指标无显著差异;萎缩、肠化及异型增生完全消失者,细胞凋亡及上述7种指标表达均显著降低(P0.05)。 结论 胃祺饮加减可有效改善慢性萎缩性胃炎患者胃黏膜细胞增殖与凋亡异常,维持胃黏膜上皮细胞增殖和凋亡之间的稳态,以维持胃黏膜上皮屏障功能的正常发挥,从而改善萎缩性胃炎的病理表现。

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69aa7096531e4c4a9ff5a8f9https://doi.org/10.70976/j.1008-0805.szgygy-2026-0208
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