IGHG1, HLA-DOB, and GABBR1: Genetic Insights into Rheumatoid Arthritis Using Mendelian Randomisation and Single-Cell RNA Sequencing

Key Points

• This research aims to explore genetic associations and expression patterns linked to rheumatoid arthritis.
• Utilized mendelian randomisation to determine causal relationships between genes and rheumatoid arthritis.
• Applied single-cell RNA sequencing to examine gene expression variations at the cellular level.
• Identified differential gene expression profiles related to rheumatoid arthritis.
• Found specific genetic associations with rheumatoid arthritis involving IGHG1, HLA-DOB, and GABBR1.
• Highlighted significant differences in gene expression in affected cells compared to controls.