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March 10, 2026Medical Mycology Case Reports0 citationsOpen Access

Redefining Ultrasound's role in early diagnosis of hepatosplenic candidiasis during neutropenia: A pediatric case report in solid tumor

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FCFrancesca CappozzoTBTeresa BattagliaMNMarta Nebiolo

Key Points

  • This case report aims to redefine ultrasound's diagnostic value for hepatosplenic candidiasis during neutropenia in pediatric patients.
  • Case report of a neutropenic child with ovarian teratoma
  • Utilized high-frequency ultrasonography to identify lesions
  • Monitored progression of hypoechoic pseudonodules to classic lesions
  • Detected hypoechoic pseudonodules in the spleen during neutropenia
  • Confirmed presence of Candida tropicalis via splenectomy
  • Highlighted the potential for early diagnosis before immune recovery

Abstract

We report a case of hepatosplenic candidiasis (HSC) in a neutropenic child with ovarian teratoma. Using high-frequency ultrasonography, we detected subtle hypoechoic pseudonodules in the spleen during profound neutropenia (ANC 30/μL), challenging the dogma that lesions only appear after immune recovery. These precursors evolved into classic "bull's-eye" lesions. Candida tropicalis was confirmed via splenectomy. This case highlights high-frequency ultrasound's role in early HSC diagnosis before neutrophil recovery.

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Cite This Study

Cappozzo et al. (2026) studied this question.

synapsesocial.com/papers/69af955970916d39fea4cceahttps://doi.org/10.1016/j.mmcr.2026.100777
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