Abstract Metal‐based nanoparticles (MNPs) are composed of metals, such as gold (Au), silver (Ag), zinc (Zn), iron (Fe), and manganese (Mn), and are utilized across various biomedical applications. The unique physicochemical profile of MNPs, characterized by tunable size, a high surface‐area‐to‐volume ratio, and distinctive optical, magnetic, and catalytic properties, facilitates applications impossible for bulk materials or standard molecular therapeutics. This review examines recent developments and modifications in the functional properties of MNPs, with particular emphasis on potentially groundbreaking applications, including NPs containing Au, Ag, Fe, and other emerging MNPs. Their applications in nanomedicine, specifically in cancer detection and treatment, wound healing, antimicrobial therapy, imaging, as well as liver and fibrosis treatment, are thoroughly discussed. Factors influencing the future clinical utility of these NPs include their interactions within the human body and the relative ease of their production. MNPs hold significant promise for advancing sophisticated diagnostic and therapeutic techniques. The review also delineates prospective future directions in this field.
Inam et al. (2026) studied this question.