March 12, 2026Stem Cell Research & Therapy0 citationsOpen Access
WDR63 enhances the chondrogenic differentiation and regenerative potential of stem cell from apical papilla by facilitating vimentin function to promote mitochondrial fission
The research aims to investigate how WDR63 influences the chondrogenic differentiation of stem cells from apical papilla (SCAPs).
Examined the interaction between WDR63 and vimentin (VIM).
Assessed the expression levels of VIM.
Investigated the role of mitochondrial fission in the differentiation process.
WDR63 interacts with VIM to enhance its expression.
Increased mitochondrial fission was observed in SCAPs associated with WDR63 expression.
Enhanced chondrogenic differentiation was confirmed in stem cells when WDR63 was present.
Abstract
WDR63 may promote chondrogenic differentiation of SCAPs by interacting with VIM and enhancing its expression, potentially through facilitating mitochondrial fission.