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Synapse
March 12, 2026Neurology and Therapy0 citationsOpen Access

Divergent Immunological and Neurotrophic Responses to CD20 Depletion in Relapsing and Progressive Multiple Sclerosis

GKGudrun KörnerTMThiemo Malte MöllenkampKJKonstantin F. Jendretzky

Key Points

  • To investigate the differing immunological responses to CD20 depletion in relapsing multiple sclerosis (RMS) versus progressive multiple sclerosis (PPMS).
  • Analyzed cytokine profiles in RMS and PPMS patients receiving ocrelizumab.
  • Compared immunological responses between the two MS subtypes.
  • Assessed treatment effects on immune modulation.
  • Found stronger cytokine-driven pathology in RMS than in PPMS.
  • Reported more significant immunomodulatory effects of ocrelizumab on cytokine profiles in RMS.
  • Indicated divergent immune mechanisms underpinning RMS and PPMS.

Abstract

Our findings support divergent immunological mechanisms in RMS and PPMS, with a stronger cytokine-driven pathology and more pronounced immunomodulatory effects of ocrelizumab on the cytokine profile in patients with RMS.

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Cite This Study

Körner et al. (2026) studied this question.

synapsesocial.com/papers/69b2579096eeacc4fcec6500https://doi.org/10.1007/s40120-026-00908-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immunology of Multiple Sclerosis2016 · 236 citations
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  3. 3IL-18 in patients with multiple sclerosis2001 · 103 citations
  4. 4Epidemiologic Evaluation of Measurement Data in the Presence of Detection Limits2004 · 1,015 citations
  5. 5CXCL9, CXCL10, CXCL11, and their receptor (CXCR3) in neuroinflammation and neurodegeneration2018 · 234 citations