PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
March 12, 2026Pain

Suzetrigine (VX-548) exhibits activity-dependent effects on human dorsal root ganglion neurons with differential pain etiology

View Full Paper
Ask AI
Bookmark
Share

Authors

MUMegan L. UhelskiMSMandee K. SchaubFEFelipe Espinosa

Discussion

Loading...

Member takes

Overview

Electrophysiology studies reveal suzetrigine modulates spontaneous pain in human dorsal root ganglion neurons, suggesting effective pain relief.

Key Points

  • The aim is to assess the efficacy of suzetrigine on human dorsal root ganglion neurons with varying pain origins.
  • Tested suzetrigine effects on neurons from patients and organ donors
  • Utilized parallel electrophysiology studies
  • Applied 10 nM suzetrigine in baths to assess spontaneous and evoked discharges
  • Suzetrigine abolished spontaneous discharges linked to neuropathic pain within minutes
  • Moderate suppression of discharges from intracellular current injection
  • Suggests potential effectiveness against spontaneous pain while minimizing evoked pain effects

Cite This Study

Uhelski et al. (2026) studied this question.

synapsesocial.com/papers/69b2580996eeacc4fcec73f8https://doi.org/10.1097/j.pain.0000000000003931
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Suzetrigine VX-548 Physical Engineering and Cellular Interaction Analysis2026
  2. 2Suzetrigine and the emergence of selective NaV1.8 inhibition in acute pain pharmacotherapy: efficacy, safety, and future clinical positioning2026
  3. 3Suzetrigine as a Novel Non-opioid Analgesic Drug in Pain Management: A Review of Clinical Evidence and Therapeutic Perspectives2025 · 4 citations
  4. 4Suzetrigine: A First-in-class Na <sub>V</sub> 1.8 Inhibitor for Opioid-free Pain Management2026
  5. 5SUZETRIGINE, A NEW SELECTIVE NaV1.8 INHIBITOR, AS A BREAKTHROUGH IN THE TREATMENT OF PAIN – A REVIEW ARTICLE2025