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March 12, 2026Ophthalmic Epidemiology0 citations

Systemic Conditions Associated with Primary Open-Angle Glaucoma and Normal Tension Glaucoma in a Large US Adult Cohort

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JJJulia H. JooKTKatherine E. TalcottRSR. P. Singh

Key Points

  • To explore the associations between systemic conditions and two types of glaucoma: primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG).
  • Analyzed a large US adult cohort
  • Used propensity score-matching for accurate comparisons
  • Examined associations between glaucoma subtypes and various systemic conditions.
  • POAG showed no association with cardiovascular or neurological conditions
  • POAG was positively linked to certain autoimmune conditions
  • NTG showed positive associations with conditions across multiple organ systems.

Abstract

POAG was not associated with cardiovascular or neurological conditions in a very large, propensity score-matched sample, but was positively associated with certain autoimmune conditions. NTG was positively associated with conditions across multiple organ systems. These findings indicate that both glaucoma subtypes likely have multifactorial etiologies of disease, one component of which may be auto-inflammatory.

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Cite This Study

Joo et al. (2026) studied this question.

synapsesocial.com/papers/69b2581996eeacc4fcec7586https://doi.org/10.1080/09286586.2026.2633607
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