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Synapse
March 12, 20261 citations

When the clock shifts: menopause timing is associated with reduced cognitive performance and gray matter volume in a population-based cohort.

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NSNitsan SchwarzDHDaniel HarlevEBEyal Bergmann

Key Points

  • The research aims to investigate the relationship between menopause timing and cognitive performance as well as brain structure.
  • Analyzed a population-based cohort
  • Assessed cognitive performance and gray matter volume
  • Examined the association with menopause timing
  • Earlier menopause is associated with lower cognitive performance
  • Earlier menopause is linked to reduced gray matter volume
  • Findings suggest a potential connection between menopause timing and cognitive decline

Abstract

In this population-based cohort, earlier menopause was associated with both lower cognitive performance and reduced gray matter volume, suggesting a potential mechanism linking earlier menopause to cognitive decline. However, the cross-sectional nature of this study prevents causal conclusions, and longitudinal research is needed to establish causal links and explore potential targeted interventions.

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Cite This Study

Schwarz et al. (2026) studied this question.

synapsesocial.com/papers/69b25b0996eeacc4fcec9619https://doi.org/10.1097/gme.0000000000002765
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Age at Menopause and Brain Atrophy Among Older Women2026
  2. 2Early menopause is associated with reduced global brain activity2026
  3. 3Cognition and the menopause transition: cross-sectional evidence from a large community cohort2026 · 2 citations
  4. 4Effect of early menopause on cognition and brain morphology in an Urban Indian Cohort2024 · 9 citations
  5. 5Cognitive functioning in perimenopause: An updated systematic review and meta-analysis.2025 · 3 citations