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March 13, 2026World Journal of Surgical Oncology0 citationsOpen Access

Evolving challenges in the management of early esophageal adenocarcinoma: from clinical staging to molecular insights

LGLorenzo GiorgiGGGiovanni Maria GarbarinoRMRenato De Martino

Key Points

  • This report aims to clarify the therapeutic balance in managing early esophageal adenocarcinoma and assess the limitations of current staging practices.
  • Exploration of international guidelines on esophageal adenocarcinoma management.
  • Analysis of surgical and endoscopic series in treatment outcomes.
  • Review of predictive modeling studies related to lymph-node metastasis.
  • Clarified risks associated with lymph-node metastasis in early esophageal adenocarcinoma.
  • Identified limitations in current clinical staging methods.
  • Discussed future directions for personalized treatment strategies.

Abstract

This report explores the evolving management of early esophageal adenocarcinoma (EAC), focusing on the therapeutic balance between endoscopic resection and esophagectomy. It synthesizes recent evidence from international guidelines, surgical and endoscopic series, and predictive modeling studies to clarify lymph-node metastasis (LNM) risk, evaluate current staging limitations, and discuss future directions in treatment stratification and personalized care.

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Cite This Study

Giorgi et al. (2026) studied this question.

synapsesocial.com/papers/69b3ab2902a1e69014ccbc20https://doi.org/10.1186/s12957-026-04285-8
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