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March 13, 20260 citations

A visible assay for evaluating the inhibitory activity of drug and antibody against HBV infection.

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HYHu YanSouthern University of Science and TechnologyYLYuxiao LiSouthern University of Science and TechnologyCLC LiuSouthern University of Science and Technology

Key Points

  • The central aim is to develop an assay for the quantitative detection and evaluation of inhibitors against HBV infection.
  • Developed a sensitive immunospot assay for detecting HBV infection
  • Evaluated the inhibitory effects of antiviral drugs and neutralizing antibodies
  • Utilized plasma samples from vaccinated individuals
  • The assay shows excellent performance for quantifying HBV infection
  • Demonstrated effectiveness in assessing the inhibitory activity of various treatments
  • Anticipated to be a reliable alternative for HBV-related research

Abstract

In this study, we report a sensitive and reliable immunospot assay for the visible quantitative detection of HBV infection. This assay demonstrates excellent performance in evaluating the inhibitory effect of antiviral drugs, neutralizing antibodies, and plasma samples from vaccinated individuals. Given its robustness and versatility, the proposed method is anticipated to be an excellent alternative assay for HBV-related research, including therapeutic development and vaccine evaluation.

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Cite This Study

Yan et al. (2026) studied this question.

synapsesocial.com/papers/69b3ace502a1e69014ccf074https://doi.org/10.1128/spectrum.02638-25
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