Relationship Between Allergen Sensitivity, Laboratory Values, and Inflammatory Markers in Patients with Asthma and/or Allergic Rhinitis

Objective: This study aimed to examine the clinical value of inflammation-related markers in pediatric asthma and to explore how these parameters are associated with the development of allergic conditions.Methods: In this retrospective analysis, 2028 children diagnosed with asthma (0–18 years) who were evaluated at the Pediatric Allergy and Immunology Clinic, Umraniye Training and Research Hospital, University of Health Sciences, between January 1, 2023, and January 1, 2024, were included. Information regarding demographic features, clinical asthma findings, coexisting allergic rhinitis, medications, allergen sensitization profiles, and laboratory data—such as complete blood count parameters, serum total IgE levels, and skin prick test outcomes—was extracted from medical records. Inflammation-related hematologic ratios, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic inflammation response index (SIRI), were computed. All statistical procedures were conducted using SPSS software (version 25.0).Results: Of the 2028 patients, 64.3% were diagnosed with AR, and 39.9% showed allergen sensitization, predominantly to house dust mite, cat dander, and pollen. Patients with allergen sensitization exhibited significantly higher total IgE, eosinophil counts, and inflammatory indices. Those with AR also had elevated IgE and eosinophil levels, with higher inflammatory indices (p 0.001).Conclusion: Asthma frequently coexists with allergic rhinitis in children. Sensitization to common allergens is common, and inflammatory markers such as total IgE, eosinophil count, NLR, SIRI, and PLR may serve as useful indicators of disease severity and allergic inflammation. These parameters may contribute to more effective evaluation and management of pediatric asthma.