Introduction: Alzheimer’s disease (AD) affects millions globally. This study explores the therapeutic mechanisms of Qingge Formula (QGF) against AD using network pharmacology and molecular docking. Methods: Active components and targets were identified via TCMSP, Swiss ADME, and GeneCards databases. PPI networks, GO, and KEGG analyses were performed, followed by molecular docking. Results: Core targets included PTGS2, EGFR, ESR1, STAT3, and SRC. GO identified 222 terms; KEGG revealed 65 pathways. Molecular docking revealed that the six key components bind to the core targets with energetically favorable conformations, among which SRC showed the highest affinity for all the components. Discussion: QGF likely modulates neuroinflammation, immunity, and synaptic plasticity pathways, with SRC as a crucial target. Conclusion: QGF demonstrates multi-component, multi-target therapeutic potential against AD.
Ma et al. (2026) studied this question.