We present a 63-year-old male with a history of chronic cystoprostatitis and urethral stricture with recurrent purpuric skin lesions and fulminant uroseptic shock. Initial treatment for suspected septic vasculitis with antibiotics and corticosteroids improved his condition, but vasculitis recurred after corticosteroid tapering. Repeated biopsies confirmed leukocytoclastic vasculitis (LCV) triggered by persistent prostate infection. To our knowledge, this is the first reported case of recurrent LCV triggered by chronic cystoprostatitis—a rare and underrecognized infectious etiology. Definitive resolution required addressing the underlying prostatitis, underscoring the importance of identifying and treating chronic infectious triggers in recurrent cutaneous vasculitis.
Dineva et al. (2026) studied this question.