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March 14, 2026Clinical and Experimental Pharmacology and Physiology0 citationsOpen Access

Mechanisms of IL‐17A Neutralisation in Alleviating Renal Fibrosis and Inflammation in Spontaneously Hypertensive Rats

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ABAnshuai BaZCZhenzhen ChenMWMeng Wu

Key Points

  • This research aims to explore how IL-17A neutralisation can reduce renal fibrosis and inflammation.
  • Used spontaneously hypertensive rats (SHRs) as a model
  • Administered IL-17A neutralising agents
  • Analyzed macrophage polarization and inflammatory pathways
  • Evaluated signaling pathways involved in renal responses
  • IL-17A neutralisation significantly reduced renal fibrosis
  • Diminished systemic and renal inflammation observed
  • Inhibition of M2 macrophage polarisation was linked to treatment
  • Downregulation of JAK/STAT, PI3K/AKT, and NF-κB pathways noted

Abstract

Our findings demonstrate that IL-17A neutralisation alleviates renal fibrosis and inflammation in SHRs. The protective effects are associated with the inhibition of M2 macrophage polarisation, suppression of the TGF-β/Smad pathway and the associated EMT process, and attenuation of systemic and renal inflammation, concomitant with the coordinated downregulation of the JAK/STAT, PI3K/AKT, and NF-κB signalling pathways.

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Cite This Study

Ba et al. (2026) studied this question.

synapsesocial.com/papers/69b4fc33b39f7826a300cdf5https://doi.org/10.1111/1440-1681.70116
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