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March 15, 2026Cancer Research

Abstract A001: Mitochondrial potential as a biomarker of T cell fitness and function in cancer immunotherapy

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Authors

KBKaty BeckermannPLPaul LindauANAlex Nesta

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Overview

Observational analysis links T cell activation and tumor microenvironment to immunotherapy responses in cancer patients.

Key Points

  • To assess mitochondrial potential as a biomarker for T cell fitness and function in cancer immunotherapy contexts.
  • Analyzed mitochondrial membrane potential (MMP) of tumor-associated T cells in patients.
  • Evaluated peripheral blood mononuclear cells (PBMC) before and after immune checkpoint inhibition (ICI).
  • Characterized T cell clones via TCRβ and single cell RNA sequencing in primary tumors.
  • Increased effector T cells were observed in patients benefiting from ICI treatment.
  • TMREhigh CD8 T cells correlated with exhaustion-like states and poor clinical response.
  • Elevated oxidative phosphorylation gene signatures were found in TMREhigh T cell populations.

Cite This Study

Beckermann et al. (2026) studied this question.

synapsesocial.com/papers/69b5ff6e83145bc643d1be65https://doi.org/10.1158/1538-7445.kidney26-a001
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