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March 15, 2026Circulation Research3 citations

Vascular Endothelial Growth Factor-D Improves Lung Vascular Integrity During Acute Lung Injury

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YYYongdae YoonUniversity of Maryland, BaltimoreLSLokesh SharmaUniversity of PittsburghWTWenwen TangYale University

Key Points

  • The study investigates the role of VEGF-D in lung vascular integrity during acute lung injury.
  • Experimental model of acute lung injury
  • Assessment of lung endothelial barrier integrity
  • Examining paracrine signaling mechanisms
  • VEGF-D improves lung vascular integrity
  • VEGF-D promotes lung endothelial barrier integrity
  • Paracrine signaling from alveolar fibroblasts contributes to lung capillary homeostasis

Abstract

This study demonstrates an unexpected protective role for VEGF-D in promoting lung endothelial barrier integrity and suggests that paracrine signaling from the alveolar fibroblast niche contributes critically to lung capillary homeostasis.

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Cite This Study

Yoon et al. (2026) studied this question.

synapsesocial.com/papers/69b5ff8083145bc643d1c39bhttps://doi.org/10.1161/circresaha.124.326094
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