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March 15, 2026npj Aging0 citationsOpen Access

Urbanization, environment, and inflammaging: insights from sub-Saharan Africa

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SBStephen W. BicklerPediatric / Congenital CardiologyMCMatchecane CossaEduardo Mondlane UniversityISIrina Mendes de SousaEduardo Mondlane University

Key Points

  • The research aims to understand how urbanization and environment influence inflammaging across diverse populations in sub-Saharan Africa.
  • Analyzed variations in inflammaging among different populations in urban and rural settings.
  • Investigated the relationship between exposure to infectious and noncommunicable diseases and levels of inflammation.
  • Considered indigenous groups and industrialized populations for comparative insights.
  • Observed lower levels of inflammaging in indigenous groups adapted to chronic infections.
  • Noted heightened inflammation in industrialized populations linked to ecological imbalance.
  • Found that environmental factors significantly influence immune-aging models.

Abstract

Abstract Emerging evidence shows that inflammaging varies across populations, challenging universal immune-aging models. Urbanization in sub-Saharan Africa—characterized by reduced exposure to infectious diseases and rising rates of noncommunicable diseases—offers a natural experiment for assessing environmental effects on inflammaging. Lower inflammaging in indigenous groups may reflect adaptation to chronic infection, whereas heightened inflammation in industrialized populations suggests ecological imbalance, underscoring the need to include diverse ecological groups in aging research.

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Cite This Study

Bickler et al. (2026) studied this question.

synapsesocial.com/papers/69b5ff8d83145bc643d1c4dfhttps://doi.org/10.1038/s41514-026-00362-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inflammaging: triggers, molecular mechanisms, immunological consequences, sex differences, and cutaneous manifestations2025
  2. 2Inflammaging: From Mechanisms to Clinical Implications and Targeted Interventions.2026
  3. 3Immunosenescence and inflammaging: Mechanisms and modulation through diet and lifestyle2025 · 32 citations
  4. 4Early-life immunological and microbial differences between East African and North European children2026
  5. 5Inflammaging is minimal among forager-horticulturalists in the Bolivian Amazon2025