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March 15, 2026American Journal of Clinical Oncology0 citations

Efficacy and Safety of Pulsed Low-Dose Rate Radiotherapy in Re-Irradiation of Recurrent Solid Tumors

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XZXinyan ZhangXuzhou Medical CollegeZLZifang LiuSun Yat-sen UniversityHJHuacong JinXuzhou Medical College

Key Points

  • This research examines the efficacy and safety of pulsed low-dose rate radiotherapy in recurrent solid tumors.
  • Evaluated pulsed low-dose rate radiotherapy (PLDR) for re-irradiation of recurrent solid tumors.
  • Analyzed patient characteristics such as IDH1 mutation status, recurrence location, and re-irradiation interval.
  • PLDR re-irradiation shows favorable efficacy and safety in recurrent solid tumors.
  • Patients with IDH1 mutation and nontemporal lobe recurrence benefit more from PLDR.
  • Longer re-irradiation intervals (>24 months) are associated with greater treatment advantages.

Abstract

PLDR re-irradiation demonstrates favorable efficacy and safety in recurrent solid tumors. For recurrent glioma, patients with IDH1 mutation, nontemporal lobe recurrence, and a re-irradiation interval >24 months appear to derive greater benefit from PLDR radiotherapy.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69b6068883145bc643d1c8f6https://doi.org/10.1097/coc.0000000000001317
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