PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
March 15, 2026Journal of the American Heart Association0 citationsOpen Access

Impact of Combined Anticoagulant and Antiplatelet Therapy in Older Patients With Atrial Fibrillation: ANAFIE Subanalysis

View Full Paper
NKNaruhiko KamogawaNational Cerebral and Cardiovascular CenterKTKazunori ToyodaNational Cerebral and Cardiovascular CenterTYTakenori YamaguchiNational Cerebral and Cardiovascular Center

Key Points

  • To assess the impact of combined anticoagulant and antiplatelet therapy on older patients with atrial fibrillation.
  • Subanalysis of patients with atrial fibrillation
  • Comparison of OAC+APD therapy vs. OAC monotherapy
  • Assessment of clinical outcomes like cardiovascular death
  • OAC+APD therapy linked to higher cardiovascular death incidence than OAC monotherapy
  • No significant differences in other clinical outcomes observed
  • DOACs suggested as preferable to warfarin for combination therapy

Abstract

In older patients with atrial fibrillation, OAC+APD therapy was associated with higher incidence of cardiovascular death than OAC monotherapy, without significant differences in other clinical outcomes. For patients requiring combination therapy, DOACs may be preferable to warfarin.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Kamogawa et al. (2026) studied this question.

synapsesocial.com/papers/69b606ea83145bc643d1d793https://doi.org/10.1161/jaha.125.047724
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Meta-analysis: Antithrombotic Therapy to Prevent Stroke in Patients Who Have Nonvalvular Atrial Fibrillation2007 · 4,825 citations
  2. 2Open-Label Randomized Trial Comparing Oral Anticoagulation With and Without Single Antiplatelet Therapy in Patients With Atrial Fibrillation and Stable Coronary Artery Disease Beyond 1 Year After Coronary Stent Implantation2019 · 202 citations
  3. 3Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation2017 · 1,383 citations
  4. 4Apixaban versus Warfarin in Patients with Atrial Fibrillation2011 · 8,991 citations
  5. 5Prevention of Bleeding in Patients with Atrial Fibrillation Undergoing PCI2016 · 1,592 citations