A higher CTI is significantly and independently associated with an increased prevalence of atrial fibrillation, with an odds ratio of 7.27.
Cross-Sectional (n=2,988)
No
Does an elevated C-reactive protein to triglyceride-glucose index (CTI) correlate with an increased prevalence of atrial fibrillation in a general adult population?
The novel C-reactive protein to triglyceride-glucose index (CTI) is strongly and independently associated with atrial fibrillation prevalence, offering superior risk discrimination compared to traditional clinical models.
Effect estimate: OR 7.27 (95% CI 5.87–9.00)
p-value: p=<0.001
Objective This study aimed to investigate the association between a novel composite biomarker, the C-reactive protein to triglyceride-glucose index (CTI) and the prevalence of atrial fibrillation (AF) in a general adult population. Methods This cross-sectional study included 2, 988 participants Clinical and laboratory data were collected to calculate the CTI. Multivariable logistic regression models were employed to evaluate the association between CTI and AF prevalence, and the dose–response relationship was assessed using restricted cubic spline (RCS) analysis. Furthermore, the association between CTI and AF risk was evaluated using the C-index, net reclassification improvement (NRI), and integrated discrimination improvement (IDI). Results Among the 2, 988 participants, CTI levels were significantly higher in the AF group compared to the non-AF group. In the fully adjusted model (adjusting for age, sex, BMI, blood pressure, glycemic indices, and lipid profiles), CTI was independently and positively associated with AF prevalence (OR 7.27, 95% CI 5.87–9.00; P 0.001). Restricted cubic spline analysis revealed a significant linear dose-response relationship between CTI and AF risk. Furthermore, adding CTI to the reference clinical model improved the C-index from 0.6828 to 0.7985, accompanied by significant improvements in the net reclassification improvement (NRI: 0.5609) and integrated discrimination improvement (IDI: 0.7182) (all P 0.001). Conclusions A higher CTI, reflecting a state of combined elevated inflammation and insulin resistance, is significantly and independently associated with an increased prevalence of atrial fibrillation. This novel index may serve as a valuable and integrative biomarker for identifying individuals at high risk for AF.
Liu et al. (2026) conducted a cross-sectional in Atrial Fibrillation (n=2,988). C-reactive protein to triglyceride-glucose index (CTI) vs. Participants without atrial fibrillation was evaluated on Association between CTI and AF prevalence (OR 7.27, 95% CI 5.87–9.00, p=<0.001). A higher CTI is significantly and independently associated with an increased prevalence of atrial fibrillation, with an odds ratio of 7.27.