What question did this study set out to answer?

To investigate a case of cognitive decline associated with Amyloid β-related angiitis (ABRA) and its treatment.

March 16, 2026Rinsho Shinkeigaku0 citationsOpen Access

Amyloid β-related angiitis (ABRA) with dural contrast enhancement

DIDaichi Imamura JIJunko Ishii SHSatoshi Hosoki

Key Points

To investigate a case of cognitive decline associated with Amyloid β-related angiitis (ABRA) and its treatment.
Conducted a brain biopsy for diagnosis after observing atypical dural contrast enhancement.
Utilized head MRI to assess brain pathology related to cognitive symptoms.
Monitored response to steroid therapy in managing symptoms and imaging findings.
Identified ABRA through brain biopsy despite atypical imaging features.
Observed significant improvement in cognitive function and imaging characteristics post-steroid therapy.
Noted inflammation in the leptomeninges extending towards brain tissue and dura.

Abstract

82歳女性．月単位で増悪していた認知機能低下が急速に進行し，頭部MRIで右頭頂葉軟膜を中心とした病変を認めた．軟膜主体の病変や脳微小出血，脳表ヘモジデローシスなどからアミロイドβ関連血管炎（amyloid β related angiitis，以下ABRAと略記）を疑ったが，硬膜造影効果が非典型であったため，脳生検を施行しABRAの診断に至った．ステロイド加療で症状・画像所見ともに改善した．本疾患の画像経過からは，軟膜にはじまる炎症が脳実質および硬膜の双方向へ進展しており，ABRAの病態に特徴的な経過を考えた．硬膜には血管炎所見は認めず，軟膜の炎症が硬膜に波及する可能性が示唆された．

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Cite This Study

Imamura et al. (2026) studied this question.

synapsesocial.com/papers/69b79dce8166e15b153ab0a7 https://doi.org/10.5692/clinicalneurol.cn-002178

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March 16, 2026Rinsho Shinkeigaku0 citationsOpen Access

Amyloid β-related angiitis (ABRA) with dural contrast enhancement

DIDaichi Imamura JIJunko Ishii SHSatoshi Hosoki

Key Points

To investigate a case of cognitive decline associated with Amyloid β-related angiitis (ABRA) and its treatment.
Conducted a brain biopsy for diagnosis after observing atypical dural contrast enhancement.
Utilized head MRI to assess brain pathology related to cognitive symptoms.
Monitored response to steroid therapy in managing symptoms and imaging findings.
Identified ABRA through brain biopsy despite atypical imaging features.
Observed significant improvement in cognitive function and imaging characteristics post-steroid therapy.
Noted inflammation in the leptomeninges extending towards brain tissue and dura.

Abstract

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Cite This Study

Imamura et al. (2026) studied this question.

synapsesocial.com/papers/69b79dce8166e15b153ab0a7 https://doi.org/10.5692/clinicalneurol.cn-002178

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