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March 16, 2026PLoS ONE0 citationsOpen Access

Expression of Concern: Local vs. systemic administration of bisphosphonates in rat cleft bone graft: A comparative study

TEThe PLOS One Editors

Key Points

  • This research aims to compare the effects of local versus systemic bisphosphonate administration in rat cleft bone grafts.
  • Comparison of local and systemic bisphosphonate administration using a rat model.
  • Analysis of control groups based on different ages of rats.
  • Examination of images from the experiments for similarity across studies.
  • Identified similarities in control images despite differences in rat ages.
  • Noted discrepancies in group sizes and experimental data presented.
  • Highlighted potential issues with results from Figs 2 and 3 compared to another study.

Abstract

After this article 1 was published, concerns were raised regarding results presented in Figs 234.Specifically: The Fig 2A Control panel of this article 1 appears similar to the Fig 4a Control panel in 2, despite the articles reporting different ages of the rats included in these control groups. The Fig 3A Control 40X and 100X images of this article 1 appear similar to the Fig 5a Control 4X and 10X images in 2, despite the articles reporting different ages of the rats in these control groups. The number of animals in each group in Fig 1A and the S1Table appears different.

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Cite This Study

The PLOS One Editors (2026) studied this question.

synapsesocial.com/papers/69b79df38166e15b153ab309https://doi.org/10.1371/journal.pone.0344844
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