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March 16, 2026Gut PathogensOpen Access

Profiling gut microbiota of colorectal cancer in Indonesia: a focus on beneficial taxa depletion

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Authors

YRYudith Annisa Ayu RezkithaAHAmal Arifi HidayatINIrene Normalina

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Overview

Profiles gut microbiota differences in colorectal cancer, indicating reduced beneficial taxa in Indonesian patients.

Key Points

  • This research aims to characterize the gut microbiota profile of colorectal cancer in Indonesia and identify key differences among groups.
  • Collected stool samples from CRC, non-CRC, and healthy controls.
  • Analyzed microbiota profiles using 16 S rRNA gene amplicon sequencing.
  • Performed data analysis with QIIME2, ANCOM-BC2, and PICRUSt2.
  • Patients with CRC showed significantly lower alpha and beta diversity compared to non-CRC and HC groups.
  • Four beneficial genera were substantially reduced in CRC patients: Roseburia, Dialister, Agathobacter, and Muribaculaceae.
  • Functional prediction analysis revealed reduced mTOR and other pathways in CRC, with upregulation of lipid metabolism pathways.

Cite This Study

Rezkitha et al. (2026) studied this question.

synapsesocial.com/papers/69b79df38166e15b153ab319https://doi.org/10.1186/s13099-026-00816-6
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