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March 16, 2026Journal of Antimicrobial Chemotherapy0 citations

Characterization of efflux pump channel of florfenicol for resistance-enhancing variant RE-CmeABC in Campylobacter

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HYHong YaoWLWenjun LiMCMengguo Chen

Key Points

  • This research aims to characterize the efflux pump channel responsible for resistance in the RE-CmeB variant of Campylobacter.
  • Utilized computational predictions to analyze the efflux channel structure.
  • Conducted experimental assays to validate computational results.
  • Identified specific high-value targets in the efflux pump for potential drug development.
  • Confirmed that the P1 efflux channel in RE-CmeB is specialized for enhanced resistance.
  • Demonstrated a strong correlation between computational predictions and experimental data.
  • Identified key targets (Q87/K89) for developing inhibitors against multidrug-resistant strains.

Abstract

Our findings reveal that the enhanced resistance is primarily due to a functional specialization of the P1 efflux channel in RE-CmeB. This elucidation, strongly supported by the concordance between computational predictions and experimental data, provides a mechanistic basis and high-value targets (Q87/K89) for the development of efflux pump inhibitors against multidrug-resistant Campylobacter.

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Cite This Study

Yao et al. (2026) studied this question.

synapsesocial.com/papers/69b79e488166e15b153ab662https://doi.org/10.1093/jac/dkag047
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