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March 16, 2026Combinatorial Chemistry & High Throughput Screening0 citations

MaiMenDong Decoction Alleviates Primary Sjögren’s Syndrome by Dual Suppression of Inflammation and Immune Dysregulation: A Synergy of Network Pharmacology and NOD/Ltj Mouse Studies

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FLFengzhi LiuXWXiao-Xin WangHLHui Liu

Key Points

  • The study aims to explore how MaiMenDong Decoction reduces inflammation and immune dysfunction in primary Sjögren’s syndrome.
  • Utilized network pharmacology to identify key pathways
  • Investigated TLR4/MyD88/NF-κB pathway activation
  • Examined Treg cell-mediated immune restoration in NOD/Ltj mice
  • Demonstrated reduced activation of TLR4/MyD88/NF-κB pathway
  • Lowered release of pro-inflammatory cytokines
  • Enhanced function of AQP5-dependent salivary secretion

Abstract

MMDT exerts its therapeutic effects on pSS through multi-target inhibition of TLR4/MyD88/NF-κB pathway activation, thereby reducing the release of pro-inflammatory cytokines, promoting Treg cell-mediated restoration of immune homeostasis, and recovering AQP5- dependent salivary secretion function. These findings collectively provide novel mechanistic evidence for the application of Traditional Chinese Medicine (TCM) in the treatment of pSS. .

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69b79e538166e15b153ab889https://doi.org/10.2174/0113862073338808251127042554
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